Mouse R-Spondin 2 / FTLS / RSPO2 Protein (Fc Tag)
2610028F08Rik,AA673245,D430027K22,ftls
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| Catalog Number | P51078-M05H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | 2610028F08Rik,AA673245,D430027K22,ftls |
| Molecular Weight | The recombinant mouse Rspo2 consists 416 amino acids and predicts a molecular mass of 47.4 kDa. |
| predicted N | Asn 24 |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE. |
| Protein Construction | A DNA sequence encoding the mouse Rspo2 (NP_766403.1) (Met1-Gly205) was expressed with the Fc region of mouse IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Signaling |Signal Transduction |Signaling Pathway |Representative pathway |Wnt Signaling pathway |Wnt Signaling Modulators | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells, consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice, they exhibited greater metastatic activity than cells derived from Wnt1 tumors. |
| Reference |