Mouse SLAMF8 / BLAME Protein (His Tag)
5830408F06Rik,Blame,SBBI42
- 100ug (NPP3495) Please inquiry
| Catalog Number | P50623-M08H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | 5830408F06Rik,Blame,SBBI42 |
| Molecular Weight | The secreted recombinant mouse SLAMF8 consists of 222 amino acids and has a predicted molecular mass of 24.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmSLAMF8 is approximately 33-38 kDa due to glycosylation. |
| predicted N | Val 21 |
| SDS-PAGE |  |
| Purity | > 80 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mouse SLAMF8 (NP_083360.2) extracellular domain (Met 1-Asp 231) was fused with the a polyhistidine tag at the C-terminus. |
| Bio-activity | Measured by its ability to bind biotinylated mouse SLAMF8 in a functional ELISA. |
| Research Area | Immunology |Innate Immunity |Monocytes/Macrophages |Co-stimulatory Molecules |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells. Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. |
| Reference |