Mouse TETHERIN / BST2 / CD317 Protein (Fc Tag)

2310015I10Rik,Bst-2,C87040,CD317,DAMP-1,GREG

Catalog Number	P51043-M01H
Organism Species	Mouse
Host	Human Cells
Synonyms	2310015I10Rik,Bst-2,C87040,CD317,DAMP-1,GREG
Molecular Weight	The recombinant mouse BST2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 360 amino acids and has a calculated molecular mass of 40 kDa. The apparent molecular mass of the monomer is approximately 4-50 kDa in SDS-PAGE under reducing conditions.
predicted N	Glu
SDS-PAGE
Purity	> 90 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the extracellular domain of mouse BST2 (Q8R2Q8) (Thr 52-Asn 151) was fused with the Fc region of human IgG1 at the N-terminus.
Bio-activity
Research Area	Cardiovascular \|Blood \|Other in Blood
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Ishikawa J, et al. (1995) Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics. 26 (3): 527-34. Viswanathan K, et al. (2011) BST2/Tetherin enhances entry of human cytomegalovirus. PLoS Pathog. 7(11):e1002332. Gifford RJ. (2011) No trespassing: ancient BST2 deletion confers protection against simian immunodeficiency virus infection of humans. Hum Mutat. 32(11).