Rabbit TrkA / NTRK1 Protein (His Tag)
NTRK1
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Catalog Number | P65159-T08H |
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Organism Species | Rabbit |
Host | Human Cells |
Synonyms | NTRK1 |
Molecular Weight | The recombinant rabbit NTRK1 consists of 393 amino acids and predicts a molecular mass of 43.4 kDa. |
predicted N | Ala 33 |
SDS-PAGE | |
Purity | > 95 % as determined by SDS-PAGE. |
Protein Construction | A DNA sequence encoding the rabbit NTRK1 (XP_008262512.1) (Ala33-Glu414) was expressed with a polyhistidine tag at the C-terminus. |
Bio-activity | |
Research Area | Cancer |Signal transduction |Receptor Tyrosine Kinases (RTKs) |
Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Background | TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma. |
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