Rat CD302 / CLEC13A Protein (His Tag)
CD302, Clec13a
- 100ug (NPP2887) Please inquiry
| Catalog Number | P80414-R08H |
|---|---|
| Organism Species | Rat |
| Host | Human Cells |
| Synonyms | CD302, Clec13a |
| Molecular Weight | The recombinant rat CD302 comprises 156 amino acids and predicts a molecular mass of 18.1 kDa. The apparent molecular mass of the recombinant protein is approximately 18 and 22 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Asp 21 |
| SDS-PAGE |  |
| Purity | (49.5+41.9) % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the rat CD302 (Met1-His165) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Cancer |Invasion microenvironment |Adhesion molecule |Cell adhesion |Lectin |C-tyep lectin | |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | CD302/CLEC13A (C-type lectin domain family 13 member A), also known as C-type lectin receptor DCL-1, is a type I transmembrane C-type lectin DCL-1/CD302. DCL-1 protein was highly conserved among the human, mouse, and rat orthologs. DCL-1 ectodomain contains only one CRD, whereas other type I transmembrane C-type lectins contain more than one domain (e.g. selectins and MMR). DCL-1 CP contains several putative motifs, including a Tyr-based internalization, a cluster of acidic amino acids, and Ser and Tyr phosphorylation motifs, suggesting that DCL-1 CP mediates not only endocytosis and late endosome targeting but also signaling. DCL-1 may be another cell/matrix adhesion receptor integrated in cell adhesion complexes and that DCL-1 dysfunction may affect APC adhesion and migration, causing suppression of APC function. |
| Reference |