Rat CD48 / SLAMF2 / BCM1 Protein (Fc Tag)
CD48, Bcm-1
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| Catalog Number | P80286-R02H |
|---|---|
| Organism Species | Rat |
| Host | Human Cells |
| Synonyms | CD48, Bcm-1 |
| Molecular Weight | The recombinant rat CD48/Fc is a disulfide-linked homodimer. The reduced monomer comprises 435 amino acids and has a predicted molecular mass of 49.5 kDa. The apparent molecular mass of the protein is approximately 38-44 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Phe 23 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the rat CD48 (P10252) (Met1-Arg216) was expressed, fused with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Cluster of Differentiation (CD) |Monocyte/Macrophage CD Antigen |Other Monocytes/Macrophages CD Antigen |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD48. CD48 protein is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 protein performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses. |
| Reference |