Rat CD52 / CDW52 Protein (Fc Tag)
CD52, Cdw52, Rb7
- 100ug (NPP1177) Please inquiry
| Catalog Number | P80298-R02H |
|---|---|
| Organism Species | Rat |
| Host | Human Cells |
| Synonyms | CD52, Cdw52, Rb7 |
| Molecular Weight | The recombinant rat CD52/Fc is a disulfide-linked homodimer. The reduced monomer comprises 287 amino acids and has a predicted molecular mass of 31.4 kDa. The apparent molecular mass of the protein is approximately 53 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Gly 24 |
| SDS-PAGE |  |
| Purity | > 70 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the rat ILCD52 (Q63064) (Met1-Ala69) was expressed, fused with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | CD52 / CDW52 is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein. It has a mature peptide comprising only 12 amino acids and is abundantly expressed on human lymphocytes. From the clinical point of view this protein is an important target for therapeutic interventions aimed at leukocyte depletion in hematological malignancies and post-transplant immunosuppression. CD52 / CDW52 may play a role in carrying and orienting carbohydrate. It is an unusually good target for complement-mediated cell lysis. |
| Reference |