Rat CDH13 / Cadherin-13 / H Cadherin Protein (Fc Tag)
CDH13
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| Catalog Number | P80280-R02H |
|---|---|
| Organism Species | Rat |
| Host | Human Cells |
| Synonyms | CDH13 |
| Molecular Weight | The recombinant rat CDH13/Fc is a disulfide-linked homodimer. The reduced monomer comprises 912 amino acids and has a predicted molecular mass of 100.5 kDa. The apparent molecular mass of the protein is approximately 102 and 52 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Ala 22 |
| SDS-PAGE |  |
| Purity | (53+40.8) % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the rat CDH13 (NP_620244.1)(Met1-Ala692) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Signaling |Signal Transduction |Cytoskeleton / ECM |Cell Adhesion |Cadherins |
| Formulation | Lyophilized from sterile 25mM MES, 0.15M NaCl, pH 6.5. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. |
| Reference |