Rat CDH13 / Cadherin-13 / H Cadherin Protein

CDH13

Catalog Number	P80280-RCCH
Organism Species	Rat
Host	Human Cells
Synonyms	CDH13
Molecular Weight	The recombinant rat CDH13 comprises 678 amino acids and predicts a molecular mass of 74.3 kDa. The apparent molecular mass of the recombinant protein is approximately 84-96 kDa in SDS-PAGE under reducing conditions.
predicted N	Ala 22
SDS-PAGE
Purity	> 90 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the rat CDH13 (NP_620244.1)(Met1-Ala692) was expressed with six amino acids (LEVLFQ) at the C-terminus.
Bio-activity
Research Area	Signaling \|Signal Transduction \|Cytoskeleton / ECM \|Cell Adhesion \|Cadherins
Formulation	Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer.
Reference	Hart AB. et al., 2012, PLoS One. 7 (8): e42646. Xu J. et al., 2012, BMC Cancer. 12: 243. Jo J. et al., 2012, Obesity (Silver Spring). 20 (8): 1683-7.