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Rat COL4A3 Protein (Fc Tag)

COL4A3

Catalog Number P80439-R01H
Organism Species Rat
Host Human Cells
Synonyms COL4A3
Molecular Weight The recombinant rat COL4A3 comprises 505 amino acids and predicts a molecular mass of 55.2 kDa. The apparent molecular mass of the recombinant protein is approximately 59 kDa in SDS-PAGE under reducing conditions due to glycosylation.
predicted N Glu
SDS-PAGE
Purity > 85 % as determined by SDS-PAGE
Protein Construction A DNA sequence encoding the rat COL4A3 (NP_001129231) (Gly1426-His1670) was expressed with Fc region of human IgG1 at the N-terminus.
Bio-activity
Research Area Signaling |Signal Transduction |Signaling Pathway |Representative pathway |Apoptosis Signaling pathway |Caspases and Regulators |
Formulation Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background COL4A3 is a major structural component of basement membranes. It is composed of 3 alpha subunits, which are encoded by 6 different genes, alpha 1 through alpha 6. Each of these alpha subunits can form a triple helix structure with 2 other subunits to form COL4A3. Autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli can cause goodpasture syndrome. COL4A3 is also linked to an autosomal recessive form of alport syndrome. COL4A3 is organized in a head-to-head conformation and each gene pair shares a common promoter.
Reference
  • Ghebrehiwet B. et al., 1992, J Leukoc Biol. 51 (6): 546-56.
  • Maziers N. et al., 2006, Nephrol Ther. 1 (2): 90-100.
  • Rana K. et al., 2005, Semin Nephrol. 25 (3): 163-70.