Rat ESAM / Endothelial Cell Adhesion Molecule Protein (Fc Tag)
ESAM
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Catalog Number | P80241-R02H |
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Organism Species | Rat |
Host | Human Cells |
Synonyms | ESAM |
Molecular Weight | The recombinant rat ESAM/Fc is a disulfide-linked homodimer. The reduced monomer comprises 463 amino acids and predicts a molecular mass of 51.2 kDa. The apparent molecular mass of the rat ESAM/Fc monomer is approximately 55-60 kDa in SDS-PAGE under reducing conditions. |
predicted N | Gln 30 |
SDS-PAGE | |
Purity | > 85 % as determined by SDS-PAGE |
Protein Construction | A DNA sequence encoding the rat ESAM (Q6AYD4) extracellular domain (Met 1-Ala 251) was fused with the Fc region of human IgG1 at the C-terminus. |
Bio-activity | |
Research Area | Cancer |Invasion microenvironment |Adhesion molecule |Cell adhesion |Cell Adhesion Molecules |Endothelial | |
Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Background | Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth. |
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