Rat IL-6R / CD126 Protein (Fc Tag, ECD)
Il6ra
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| Catalog Number | P81072-R02H |
|---|---|
| Organism Species | Rat |
| Host | Human Cells |
| Synonyms | Il6ra |
| Molecular Weight | The recombinant rat Il6r consists 583 amino acids and predicts a molecular mass of 64.8 kDa. |
| predicted N | Leu 20 |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE. |
| Protein Construction | A DNA sequence encoding the rat Il6r (NP_058716.2) (Met1-Pro364) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Innate Immunity |Monocytes/Macrophages |Monocyte Markers |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer. |
| Reference |