Rat IL20RB Protein (Fc Tag)
IL20RB
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Catalog Number | P80187-R02H |
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Organism Species | Rat |
Host | Human Cells |
Synonyms | IL20RB |
Molecular Weight | The recombinant rat IL20RB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 447 amino acids and has a predicted molecular mass of 50.2 kDa. The apparent molecular mass of the protein is approximately 61 kDa in SDS-PAGE under reducing conditions. |
predicted N | Phe 22 |
SDS-PAGE | |
Purity | > 70 % as determined by SDS-PAGE |
Protein Construction | A DNA sequence encoding the rat IL20RB (B8K1X9) (Met1-Pro227) was expressed, fused with the Fc region of human IgG1 at the C-terminus. |
Bio-activity | |
Research Area | Cancer |Invasion microenvironment |Angiogenesis |Cytokines / Chemokines in Angiogenesis |Interleukins |
Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Background | IL20RB belongs to the type II cytokine receptor family. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors. They are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family. IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20. |
Reference |