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Rat IL20RB Protein (His Tag)

IL20RB

Catalog Number P80187-R08H
Organism Species Rat
Host Human Cells
Synonyms IL20RB
Molecular Weight The recombinant ratIL20RB comprises 217 amino acids and predicts a molecular mass of 24.6 kDa. The apparent molecular mass of the ratIL20RB is approximately 32-36 kDa in SDS-PAGE under reducing conditions due to glycosylation.
predicted N Phe 22
SDS-PAGE
Purity > 91 % as determined by SDS-PAGE
Protein Construction A DNA sequence encoding the rat IL20RB (B8K1X9) (Met1-Pro227) was expressed, fused with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area Cancer |Invasion microenvironment |Angiogenesis |Cytokines / Chemokines in Angiogenesis |Interleukins
Formulation Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background IL20RB belongs to the type II cytokine receptor family. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors. They are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family. IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20.
Reference
  • Zhu H, et al. (2009) Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines. Hepatobiliary Pancreat Dis Int. 8(4):402-6.
  • Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.
  • Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5):445-51.