Rat IL4R / Il4ra Protein (His Tag)

IL4R,Il4ra

100ug (NPP3067) Please inquiry

Catalog Number	P80198-R08H
Organism Species	Rat
Host	Human Cells
Synonyms	IL4R,Il4ra
Molecular Weight	The recombinant rat IL4R comprises 218 amino acids and predicts a molecular mass of 25.3 kDa.
predicted N	Ile 26
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the rat IL4R (Q63257-1) (Met1-Arg232) was expressed, fused with a polyhistidine tag at the C-terminus.
Bio-activity	Measured by its ability to bind biotinylated mouse IL4-His (P51084-M08B) in a functional ELISA.
Research Area	Cancer \|Invasion microenvironment \|Angiogenesis \|Cytokine & Receptor \|Interleukin & Receptor \|Other Interleukin & Receptor \|
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD124, also known as interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.
Reference	Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.