Rhesus ADAM8 Protein (His Tag)

ADAM8

Catalog Number	P90278-C08H
Organism Species	Rhesus
Host	Human Cells
Synonyms	ADAM8
Molecular Weight	The recombinant rhesus ADAM8 comprises 488 amino acids and has a calculated molecular mass of 53.6 KDa.
predicted N	Arg 21
SDS-PAGE
Purity	(50.8+34.6) % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the rhesus ADAM8 (XP_002805919.1) (Met1-Pro497) was expressed with a polyhistidine tag at the C-terminus.
Bio-activity	Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2, R&D Systems, Catalog # ES003. The specific activity is > 0.5 pmols/min/μg.
Research Area	Signaling \|Signal Transduction \|Cellular Senescence and Pathways in Aging \|Apoptosis \|Apoptosis Receptors \|Receptor Processing \|
Formulation	Lyophilized from sterile 1
Background	ADAM8, also known as CD156, is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM8 is possiblely involved in extravasation of leukocytes As a metalloprotease, ADAM8 also may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma.
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