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Rhesus B7-H5 / GI24 / VISTA Protein (ECD, His Tag)

B7-H5, GI24, VISTA

Catalog Number P90801-K08H
Organism Species Rhesus
Host Human Cells
Synonyms B7-H5, GI24, VISTA
Molecular Weight The recombinant rhesus C10orf54 consists 173 amino acids and predicts a molecular mass of 19.6 kDa.
predicted N Phe 33
SDS-PAGE
Purity > 95 % as determined by SDS-PAGE.
Protein Construction A DNA sequence encoding the rhesus C10orf54 (NP_001177807.1) (Met1-Ala194) was expressed with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area Immunology |Innate Immunity |Monocytes/Macrophages |Co-stimulatory Molecules
Formulation Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background C10orf54, also known as GI24, belongs to the immunoglobulin superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.
Reference
  • Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36(1):40-5.
  • Deloukas P, et al. (2004) The DNA sequence and comparative analysis of human chromosome 10. Nature. 429(6990):375-81.
  • Colland F, et al. (2004) Functional proteomics mapping of a human signaling pathway. Genome Res. 14(7):1324-32.