Rhesus CD122 / IL-2RB Protein (Fc Tag)

CD122, IL-2RB

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Catalog Number	P90328-C02H
Organism Species	Rhesus
Host	Human Cells
Synonyms	CD122, IL-2RB
Molecular Weight	The recombinant rhesus IL2RB consists of 451 amino acids and predicts a molecular mass of 51.4 kDa.
predicted N	Ala 27
SDS-PAGE
Purity	> 90 % as determined by SDS-PAGE.
Protein Construction	A DNA sequence encoding the rhesus IL2RB (NP_001244989.1) (Met1-Asp239) was expressed with the Fc region of human IgG1 at the C-terminus.
Bio-activity
Research Area	Immunology |Cytokines & Growth Factors |Cytokine & Receptor |Interleukin & Receptor |Other Interleukin & Receptor
Formulation	Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.
Reference	Foss F. (2006) Clinical experience with denileukin diftitox (ONTAK). Semin Oncol. 33(1 Suppl 3): 11-6. Sprent J, et al. (2001) T cell death and memory. Science. 293(5528): 245-8. Teshigawara K, et al. (1987) Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med. 165 (1): 223-38.