Rhesus CD122 / IL-2RB Protein (His Tag)
CD122, IL-2RB
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Catalog Number | P90328-C08H |
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Organism Species | Rhesus |
Host | Human Cells |
Synonyms | CD122, IL-2RB |
Molecular Weight | The recombinant rhesus IL2RB consists of 224 amino acids and predicts a molecular mass of 26.1 kDa. |
predicted N | Ala 27 |
SDS-PAGE | |
Purity | > 95 % as determined by SDS-PAGE. |
Protein Construction | A DNA sequence encoding the rhesus IL2RB (NP_001244989.1) (Met1-Asp239) was expressed with a polyhistidine tag at the C-terminus. |
Bio-activity | |
Research Area | Immunology |Cytokines & Growth Factors |Cytokine & Receptor |Interleukin & Receptor |Other Interleukin & Receptor |
Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Background | Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development. |
Reference |