Rhesus CD200 Protein (Fc Tag)
CD200
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| Catalog Number | P90230-C02H |
|---|---|
| Organism Species | Rhesus |
| Host | Human Cells |
| Synonyms | CD200 |
| Molecular Weight | The recombinant rhesus CD200 comprises 443 amino acids and has a calculated molecular mass of 49.6 KDa. |
| predicted N | Gln 31 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the rhesus CD200 (NP_001244473.1) (Met1-Gly232) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | Immobilized human CD200R1-His (P11218-H08H) at 10 μg/ml (100 μl/well) can bind Rhesus CD200-Fc, The EC50 of Rhesus CD200-Fc is 10.1-23.6 ng/ml. |
| Research Area | Neuroscience |Neurology process |Neuroinflammation |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in a number of human malignancies. In addition, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion. |
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