Rhesus IL18RAP Protein (His Tag)
IL18RAP
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| Catalog Number | P90122-C08H |
|---|---|
| Organism Species | Rhesus |
| Host | Human Cells |
| Synonyms | IL18RAP |
| Molecular Weight | The recombinant rhesus IL18RAP comprises 578 amino acids and has a calculated molecular mass of 65.4 KDa. |
| predicted N | Phe 20 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the rhesus IL18RAP (XP_001108108.1) (Met1-Arg356) was expressed, fused with a polyhistidine tag at the C-terminus. |
| Bio-activity | Measured by its binding ability in a functional ELISA. Immobilized Rhesus 18RAP-His at 10 μg/ml (100 μl/well) can bind biotinylated Rhesus IL18 (P90011-C07E) with a linear range of 0.16-2.5 μg/ml. |
| Research Area | Cancer |Signal transduction |Cellular Senescence and Pathways in Aging |Apoptosis |Intracellular |NF-kB (NFkB) Pathway | |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the aetiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations. |
| Reference |