Rhesus IL6 / Interleukin-6 Protein
IL6
- 100ug (NPP1775) Please inquiry
| Catalog Number | P90197-CNAE |
|---|---|
| Organism Species | Rhesus |
| Host | E. coli |
| Synonyms | IL6 |
| Molecular Weight | The recombinant rhesus IL6 consists of 185 amino acids and has a calculated molecular mass of 21 kDa. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the the rhesus IL6 (NP_001036198.2 ) (Pro29-Met212) was expressed and purified. |
| Bio-activity | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.3-1.5 ng/mL. |
| Research Area | Developmental Biology |Transcription Factor & Regulator |HIF Transcription Factors |
| Formulation | Lyophilized from sterile 50% acetonitrile, 0.1% TFA 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity. |
| Reference |